참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 6-iodo-2,3-dihydro-1H-indole-2,3-dione | HCID 14387274 | — |
| 촉매 | chromium (VI) trioxide | HCID 10219390 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Acetic Anhydride | HCID 7918 | — |
| 생성물 | 7-Iodo-1H-benzo[d][1,3]oxazine-2,4-dione | HCID 18929920 | 81.8% |
반응 단계
To a stirred warm (80° C.) solution of 6-iodo-1H-indole-2,3dione (3.0 g, 11 mM) in acetic acid (10 mL) and acetic anhydride (10 mL) was added in small portions chromium trioxide (1.83 g, 18.3 mM) while maintaining the temperature of the reaction mixture at 80°-90° C. The reaction mixture was then heated at 80° C. for 10 min, cooled and poured into water. The resulting mixture was filtered and the collected solids dried to provide the title compound as a yellow solid (2.6 g, 81.8%); MS(CI): 290 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05599814 |
|---|
| 출처 데이터셋 | uspto-grants-1997_02 |
|---|
| ORD ID | ord-538c5ab905094dd6a93d5d5fdc38ecb0 |
|---|
| 출처 메모 | uspto-grants-1997_02 |
|---|
