Pyridine → 1-Benzyl-3-trifluoromethyl-3-(toluenesulfonyloxymethyl)pyrrolidine

HRID 1450094

반응식

HRID 1450094 반응식
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([C:15]([F:18])([F:17])[F:16])([CH2:13][OH:14])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]1(C)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.N1C=CC=C[CH:31]=1>C(Cl)Cl>[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([C:15]([F:17])([F:18])[F:16])([CH2:13][O:14][S:25]([C:22]2[C:23]([CH3:31])=[CH:24][CH:19]=[CH:20][CH:21]=2)(=[O:26])=[O:27])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 1049Pyridine2회HCID 73974-Toluenesulfonyl chlorideHCID 19691277(1-Benzyl-3-trifluoromethyl-pyrrolidin-3-YL)-methanol

생성물 1

HCID 867502991-Benzyl-3-trifluoromethyl-3-(toluenesulfonyloxymethyl)pyrrolidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

The compound from step 456b (1.61 g) was dissolved in dry pyridine, and the solution was cooled to 0° C. To this was added 1.458 g of p-toluenesulfonyl chloride in 4 mL of dry pyridine, and the reaction was stirred at 0.C. for 4 days. The mixture was diluted with 300 mL of methylene chloride, then washed with water and brine and dried. Removal of the solvent gave 2.81 g of the title compound.

후처리

  1. washwashed with water and brine
  2. customdried
  3. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-62fd8a4ee054423892857e0ce0e13660
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05599816

연결된 노트

불러오는 중…