HCID 67646998, 화합물 → 3-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine

HRID 1450099노트

반응식

HRID 1450099 반응식
[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][N:15](CC2C=CC=CC=2)[CH2:14]1)[CH:10]1[CH2:12][CH2:11]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([NH:8][CH:9]([CH:13]1[CH2:17][CH2:16][NH:15][CH2:14]1)[CH:10]1[CH2:11][CH2:12]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

4

반응물 1

HCID 67646998HCID 67646998, 화합물

생성물 1

HCID 196914723-(1-(BOC-amino)-1-cyclopropyl-methyl)pyrrolidine수율 35.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A sample (548 mg) of the compound from step 470d was dissolved in methanol, 140 mg of 10% Pd/C was added, and the mixture was hydrogenated at 4 arm H2 for 42 hours at room temperature. The solution was filtered, and the solvent was removed to give 140 mg of the title compound.

후처리

  1. filtrationThe solution was filtered
  2. customthe solvent was removed

출처 및 근거

ORD 기록
ord-1c5f3cedde6f49e5b85f80ea76afab0a
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05599816

반응 노트

불러오는 중…