Water → Methyl phenethylcarbamate

HRID 1450271

반응식

HRID 1450271 반응식
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(N(CC)CC)C.Cl[CH2:18][O:19][CH:20]=[O:21].O>O1CCCC1>[CH3:18][O:19][C:20]([NH:9][CH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)=[O:21]

참가 물질

6

반응물 4

HCID 962WaterHCID 1001PhenethylamineHCID 8471TriethylamineHCID 17803410Chloromethyl formate

생성물 1

HCID 4380476Methyl phenethylcarbamate수율 97.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a cold solution consisting of phenethylamine (20g,0.16mol) in tetrahydrofuran (900 mL) was added triethylamine (23 mL, 0.16 mol). To this solution was added dropwise chloromethylformate (64 mL, 0.8 mol). The reaction mixture was then stirred overnight water (450 mL) was added and the layers were separated. The organic layer was washed successively with water (1×200mL) and brine (1×200mL). The organic solvent was dried (anhydrous magnesium sulfate), filtered and concentrated to give the title compound (28 g, 94% yield).

후처리

  1. additionwas added
  2. customthe layers were separated
  3. washThe organic layer was washed successively with water (1×200mL) and brine (1×200mL)
  4. dry with materialThe organic solvent was dried (anhydrous magnesium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7ba537965e054dbcaf88d63a2f6e216f
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602145

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