Sodium methanolate methanol → trans-(+/-)-5-[[(4-Fluorophenyl)sulfonyl]methyl]tetrahydro-3-furanthiol

HRID 1450287노트

반응식

HRID 1450287 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C@@H:12]2[O:16][CH2:15][C@@H:14]([S:17]C(=O)C)[CH2:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C[O-].[Na+].CO>O1CCCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C@@H:12]2[O:16][CH2:15][C@@H:14]([SH:17])[CH2:13]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 23694274Sodium methanolate methanolHCID 86750317Ethanethioic acid trans-(+/-)-S-[5-[[(4-fluorophenyl)sulfonyl]methyl]tetrahydro-3-furanyl]ester

생성물 1

HCID 86750319trans-(+/-)-5-[[(4-Fluorophenyl)sulfonyl]methyl]tetrahydro-3-furanthiol수율 63.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound is prepared by the procedure of Example 16 using 0.955 g of product from Example 31, 0.72 ml of 25% sodium methoxide/methyl alcohol and 10 ml of tetrahydrofuran to give 0.523 g of the desired product.

출처 및 근거

ORD 기록
ord-16a447dd27174f948c2fd98de36566f0
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602118

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