Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Deuterium Oxide → 3-[[5-[(Acetylhydroxyamino)methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid monosodium salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Deuterium Oxide | HCID 24602 | — |
| 반응물 | 3-[[5-[[Acetyl(phenylmethoxy)amino]methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt | HCID 131719843 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 3-[[5-[(Acetylhydroxyamino)methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid monosodium salt | HCID 131719845 | 84.9% |
반응 단계
A mixture of 0.010 g of product from Example 75, 0.014 g of 10% palladium/carbon, and 1 ml of deuterium oxide is reduced in a Parr apparatus for 2 hours at 30 psi. The reaction solution is filtered and lyophilyzed to give 0.007 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05602118 |
| 출처 데이터셋 | uspto-grants-1997_02 |
| ORD ID | ord-8ee47fa5cba44378ae4adcb6317f3331 |
| 출처 메모 | uspto-grants-1997_02 |