Imidazole → (Dimethoxyphosphinyl)[[(1,1-dimethylethyl)dimethylsilyl]oxy]acetic acid (4-nitrophenyl)methyl ester

참여 물질

반응 단계

To a mixture of 3.48 g of product from Example 97 and 12 ml of dimethylformamide is added 1.86 g of t-butyldimethylsilyl chloride and 1.86 g of imidazole. After stirring the reaction at room temperature for 2 hours, the mixture is diluted with ethyl acetate/diethyl ether, washed 5 times with water, once with saturated sodium bicarbonate and once with saturated sodium chloride. The organic layer is dried, filtered and concentrated in vacuo to give 3.90 g of the desired silylated product.

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