2-(4-Aminophenyl)benzonitrile → 7-[(2'-Cyanobiphenyl-4-yl)amino]-5-ethylpyrazolo[1,5-a]pyrimidine

HRID 1450403노트

반응식

HRID 1450403 반응식
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([CH2:11][CH3:12])[CH:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]#[N:27])=[CH:16][CH:15]=1>C(O)C>[C:26]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:2]2[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=[C:4]([CH2:11][CH3:12])[CH:3]=2)=[CH:19][CH:18]=1)#[N:27]

참가 물질

4

반응물 2

HCID 13939262-(4-Aminophenyl)benzonitrileHCID 105354107-Chloro-5-ethylpyrazolo[1,5-a]pyrimidine

생성물 1

HCID 199759777-[(2'-Cyanobiphenyl-4-yl)amino]-5-ethylpyrazolo[1,5-a]pyrimidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.4 g (7.7 mmol) of the chloride from Example 1, Step B and 1.5 g (7.7 mmol) 4-Amino-2'-cyanobiphenyl were heated in 30 ml dry ethanol for 5 h. After removal of the solvent in vacuo the nitrile was obtained in colorless crystals from ethanol,

후처리

  1. customAfter removal of the solvent in vacuo the nitrile
  2. customwas obtained in colorless crystals from ethanol

출처 및 근거

ORD 기록
ord-9d9b46476e6e49ad8be937f6ba4ba0f3
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602136

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