Water → N-Chloro-4-methoxybenzamide

HRID 1450640노트

반응식

HRID 1450640 반응식
[CH3:1][O:2][C:3]1C=CC(C=NO)=[CH:5][CH:4]=1.[Cl:12][N:13]1[C:17](=[O:18])[CH2:16][CH2:15][C:14]1=O.O>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:16]([C:17]([NH:13][Cl:12])=[O:18])=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 94712N-[(4-Methoxyphenyl)methylidene]hydroxylamine

생성물 1

HCID 21579386N-Chloro-4-methoxybenzamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Dissolved in 65 ml of dimethylformamide were 6.5 g (43 mmol) of 4 -methoxybenzaldoxime, followed by the gradual addition of 6.3 g (47 mmol) of N-chlorosuccinimide at room temperature. After the resultant mixture was stirred for 3 hours, 300 ml of water were added to the reaction mixture. The mixture thus formed was extracted with ethyl ether. The ether layer was washed with saturated saline and then dried over anhydrous magnesium sulfate. The solvent was distilled off, whereby 4-methoxybenzhydroxamic acid chloride was obtained.

후처리

  1. customThe mixture thus formed
  2. extractionwas extracted with ethyl ether
  3. washThe ether layer was washed with saturated saline
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-aa38c33726504debb3a09f7882b2b56d
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602160

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