Water → 4-(Acetamidomethyl)benzoic acid
반응식
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[C:12]([O-])(=[O:14])[CH3:13].[Na+].O>C(O)(=O)C>[C:12]([NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=1)(=[O:14])[CH3:13]참가 물질
5
실험 절차
A mixture of 4-aminomethylbenzoic acid (Aldrich, 1.51 g, 0.01 mol) and anhydrous sodium acetate (1.5 g, 0.018 mol) in glacial acetic acid (5 mL) was heated at reflux for 18 h. On cooling, the mixture was poured into cold water (50 mL). The precipitate was separated by filtration and washed several times with cold water. The cake was recrystallized from water to give 1.4 g (72.5%) of the title compound as a white powder, mp 195° C.
후처리
- temperaturewas heated
- temperatureat reflux for 18 h
- temperatureOn cooling
- customThe precipitate was separated by filtration
- washwashed several times with cold water
- customThe cake was recrystallized from water
출처 및 근거
- ORD 기록
- ord-12f1e27cae5b4c7a9f2621ee04a97023
- 출처 데이터셋
- uspto-grants-1997_02
- 특허 번호
- US05602277
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