HCID 85272219, 화합물 → HCID 85247288, 화합물

HRID 1451107노트

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HRID 1451107 반응식
[OH:1][N:2]=[CH:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]>C(O)C.[Pt]=O>[NH2:14][C:12]1[CH:11]=[C:6]([CH:5]=[C:4]([CH:3]=[N:2][OH:1])[CH:13]=1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 1

HCID 85272219HCID 85272219, 화합물

생성물 1

HCID 85247288HCID 85247288, 화합물수율 64%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

A mixture of methyl 3-[(N-hydroxylimino)methyl]-5-nitrobenzoate (2.0 g, 0.009 mol) in ethanol (150 mL) was hydrogenated in the presence of platinum oxide (0.25 g) at 30 psi for 0.5 h. The catalyst was removed by filtration through Celite and the filtrate was concentrated. The residue was recrystallized from ethyl acetate-hexane to give 1.1 g (64%) of methyl 3-amino-5-[(N-hydroxylimino)methyl]benzoate as an off-white solid, mp 160°-162° C.

후처리

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-72bab7d9f7594470b501cc4b41296762
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602277

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