1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane → Bis-Aminoethylglycol

HRID 1451148

반응식

HRID 1451148 반응식
[N:1]([CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][N:12]=[N+]=[N-])=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH2:1][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH2:12]

참가 물질

4

반응물 2

HCID 108457051-Azido-2-[2-(2-azidoethoxy)ethoxy]ethaneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 70248Bis-Aminoethylglycol수율 97%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

The diazide (17) (3.55 g, 17.85 mmol) in THF (10 mL) was added dropwise into a cold (-5° C.) stirred mixture of lithium aluminum hydride (1.83 g, 48.2 mmol) in THF (20 mL). The reaction mixture was kept at -5° C. and carefully quenched with water (10 mL). The THF layer was filtered to remove the inorganic salts, dried over Na2SO4, and evaporated in vacuo to afford the diamine (18) (2.56 g, 97% yield).

후처리

  1. customwas kept at -5° C.
  2. customcarefully quenched with water (10 mL)
  3. filtrationThe THF layer was filtered
  4. customto remove the inorganic salts
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-7f65df5ac9d149aea28e3e9ee7157ad3
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05604095

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