1-(4-(2-Hydroxyethoxy)phenyl)propan-2-one → N-[2-(4-(2-Hydroxyethoxy)phenyl)-1-methylethyl]-2-(2-methyl-thiazol-4-yl)morpholine
반응식
O[C:2]1([C:8]2[N:9]=[C:10]([CH3:13])[S:11][CH:12]=2)[O:7][CH2:6][CH2:5][NH:4][CH2:3]1.[OH:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](=O)[CH3:26])=[CH:20][CH:19]=1>>[OH:14][CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([N:4]2[CH2:5][CH2:6][O:7][CH:2]([C:8]3[N:9]=[C:10]([CH3:13])[S:11][CH:12]=3)[CH2:3]2)[CH3:26])=[CH:20][CH:19]=1참가 물질
3
실험 절차
Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-methyl-thiazol-4-yl)morpholine with 1-[4-(2-hydroxyethyoxy)phenyl]propan-2-one followed by purification on a silica gel column using methylene chloride as eluant.
후처리
- customfollowed by purification on a silica gel column
출처 및 근거
- ORD 기록
- ord-cd38ab97cabb4c70be86761fd5d0d707