1-bromo-3-ethyl-5-nitroBenzene → 3-Bromo-5-ethylaniline
반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:10]([O-])=O)[CH:5]=[C:6]([CH2:8][CH3:9])[CH:7]=1>C(O)(=O)C.C(O)C.[Fe]>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([CH2:8][CH3:9])[CH:7]=1)[NH2:10]참가 물질
5
실험 절차
Dissolve 3-bromo-5-ethylnitrobenzene (6.21g, 27mmol) in acetic acid (40mL) and ethanol (30mL) and treat with iron powder (2.7g). Reflux for 3 hours, filter through Celite and evaporate the solvent in vacuo. Purify by silica gel chromatography to give 3-bromo-5-ethylaniline.
후처리
- temperatureReflux for 3 hours
- filtrationfilter through Celite
- customevaporate the solvent in vacuo
- customPurify by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-b46620aeb06f4cf682d50726ac488bb8
- 출처 데이터셋
- uspto-grants-1997_02
- 특허 번호
- US05606063
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