Oxalyl chloride → 4-Fluorobenzoyl isocyanate

HRID 1452516

반응식

HRID 1452516 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C(Cl)(=O)[C:12](Cl)=[O:13]>ClCCl>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[C:12]=[O:13])=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 715724-Fluorobenzamide

생성물 1

HCID 27333754-Fluorobenzoyl isocyanate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.5 g of 4-fluorobenzamide was dissolved in 20 ml of dichloromethane and 2.3 ml of oxalyl chloride was slowly added thereto at room temperature, and then the mixutre was heated and refluxed for 16 hours. When the reaction was completed, the reaction mixture was cooled to room temperature and the solvent was distilled under reduced pressure to produce the titled compound as a oil. Without purification processes, next process was proceeded.

후처리

  1. temperaturerefluxed for 16 hours
  2. temperaturethe reaction mixture was cooled to room temperature
  3. distillationthe solvent was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-6f7e71e2837f4a44b05ef245dccab01d
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07473700B2

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