2-Iodophenol → HCID 14912767, 화합물

HRID 1452721노트

반응식

HRID 1452721 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1)#[CH:2].I[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19]>>[C:9]([C:6]1[CH:7]=[CH:8][C:3]([C:1]2[O:19][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[CH:2]=2)=[CH:4][CH:5]=1)(=[O:11])[CH3:10]

참가 물질

3

반응물 2

HCID 107842-IodophenolHCID 51236261-(4-Ethynylphenyl)ethan-1-one

생성물 1

HCID 14912767HCID 14912767, 화합물

실험 절차

The general procedure was used to convert 1-(4-Ethynyl-phenyl)-ethanone and 2-iodophenol to the title product. Purification by flash chromatography (10% ethyl acetate in hexanes as the eluent) gave the analytically pure product as a white solid (326 mg, 69% yield). 1H NMR (300 MHz, CDCl3) δ 8.02 (d, J=8.67, 2H), 7.92 (d, J=8.67, 2H), 7.60 (d, J=7.72, 1H), 7.52 (d, J=7.35, 1H), 7.35-7.22 (m, 2H), 7.14 (s, 1H), 2.62 (s, 3H). 13C NMR (75 MHz, CDCl3) δ 197.33, 155.18, 154.50, 136.48, 134.55, 128.91, 128.87, 125.14, 124.75, 123.24, 121.32, 111.35, 103.65, 26.62. HRMS El calcd for C16H12O2—236.0837, Found—236.0835. mp.—168-170° C. (lit., 3168-170° C.).

출처 및 근거

ORD 기록
ord-d8bd7f4dd2ca4bdc89cf3dd6b55168e5
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07473786B1

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