ethyl (2Z)-3-iodoprop-2-enoate → HCID 85434382, 화합물

HRID 1452802노트

반응식

HRID 1452802 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1)#[CH:2].[CH2:12]([O:14][C:15](=[O:19])/[CH:16]=[CH:17]\I)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:19])[CH:16]=[CH:17][C:2]#[C:1][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1)[CH3:13]

참가 물질

3

반응물 2

HCID 643843ethyl (2Z)-3-iodoprop-2-enoateHCID 51236261-(4-Ethynylphenyl)ethan-1-one

생성물 1

HCID 85434382HCID 85434382, 화합물

실험 절차

The general procedure was used to convert 1-(4-Ethynyl-phenyl)-ethanone and (Z)-ethyl-3-iodoacrylate to the title product. Purification by flash chromatography (440 mg, 20% ethyl acetate in hexane as the eluent) gave the analytically pure product as a light yellow oil (92% yield). 1H NMR (400 MHz, CDCl3) δ 7.93-7.90 (d, J=8.5, 2H), 7.60-7.58 (d, J=8.5, 2H), 6.38-6.35 (d, J=11.4, 1H), 6.20-6.18 (d, J=11.4, 1H), 4.28-4.23 (q, J=7.1, 2H), 2.58 (s, 3H), 1.34-1.30 (t, J=7.1, 3H). 13C NMR (100MHz, CDCl3) δ 197.09, 164.54, 136.87, 132.09, 129.43, 128.24, 127.39, 122.22. 99.65, 89.11, 60.53, 26.59, 14.29. Anal. Calcd. for C15H14O3: C, 74.36; H, 5.82; Found C, 74.31; H, 5.97.

출처 및 근거

ORD 기록
ord-a7b4ef8cad3441aca0651cfc29c26716
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07473797B2

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