(2-Bromo-4-fluorobenzo[d]thiazol-6-yl)methanol → 2-Bromo-4-fluorobenzo[d]thiazole-6-carbaldehyde
반응식
[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH2:11][OH:12])[CH:8]=[C:7]([F:13])[C:5]=2[N:6]=1>C1COCC1.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH:11]=[O:12])[CH:8]=[C:7]([F:13])[C:5]=2[N:6]=1참가 물질
4
실험 절차
A mixture of (2-bromo-4-fluorobenzo[d]thiazol-6-yl)methanol (0.269 g, 1.03 mmol) and manganese (IV) oxide (activated, 85%, 1.47 g, 14.4 mmol) in THF (15 mL) was stirred at rt for 16 hr. Solid material was removed by filtration through Celite® 545, and the filtrate was concentrated under vacuum. The residue was diluted with AcOEt, washed with brine, and dried over anhydrous MgSO4. Evaporation of solvent under vacuum gave the title compound (0.136 g, 61% yield) as a white solid.
후처리
- customSolid material was removed by filtration through Celite® 545
- concentrationthe filtrate was concentrated under vacuum
- additionThe residue was diluted with AcOEt
- washwashed with brine
- dry with materialdried over anhydrous MgSO4
- customEvaporation of solvent under vacuum
출처 및 근거
- ORD 기록
- ord-5010c84d973641a3844d488e36ecac98
- 출처 데이터셋
- uspto-grants-2009_01
- 특허 번호
- US07473784B2
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