Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| 반응물 | 4-(2-Butynyloxy)-6-chloropyrimidine | HCID 12137602 | — |
| 생성물 | 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine | HCID 57672951 | 61.4% |
반응 단계
0.3 g of 4-chloro-6-(2-butynyloxy)pyrimidine and 0.25 g of 3-trifluoromethylpiperidine were mixed and left for 10 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.30 g of 4-(2-butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine (hereinafter, referred to as Compound (24)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732448B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-9c10e1391ad14fabbbc89f7c5e5cfdbd |
| 출처 메모 | uspto-grants-2010_06 |