D-Leucine, methyl ester → (R)-methyl 4-methyl-2-(5-methyl-1H-indole-2-carboxamido)pentanoate

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Prepared in a similar manner to example 4 using 5-Methyl-1H-indole-2-carboxylic acid and D-leucine methyl ester. Yield: 50%. 1H NMR (500 MHz, CDCl3): δ0.98(d, 3H, J=6.3 Hz), 1.00(d, 3H, J=6.1 Hz), 2.44 (s, 3H), 3.784(s, 3H), 4.87(m, 1H), 6.56 (d, 1H, J=8.39 Hz), 6.85 (dd, 1H, J=1.94 Hz, J=0.68 Hz), 7.12 (dd, 1H, J=8.46 Hz, J=1.55 Hz), 7.31(d, 1H, J=8.45 Hz), 7.42 (s, 1H). MS (MH+, 303).

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