D-Leucine, methyl ester → (R)-methyl 2-(4-fluoro-3-methylbenzamido)-4-methylpentanoate

반응식

[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[CH3:11].[CH3:12][O:13][C:14](=[O:21])[C@@H:15]([CH2:17][CH:18]([CH3:20])[CH3:19])[NH2:16]>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:16][C@H:15]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:14]([O:13][CH3:12])=[O:21])=[O:8])=[CH:4][C:3]=1[CH3:11]

참가 물질

반응물 2

HCID 89967D-Leucine, methyl ester

HCID 2428284-Fluoro-3-methylbenzoic acid

생성물 1

HCID 57527876(R)-methyl 2-(4-fluoro-3-methylbenzamido)-4-methylpentanoate

실험 절차

Prepared in a similar manner to example 4 using 4-fluoro-3-methylbenzoic acid and D-leucine methyl ester. MS (M+H, 282).

출처 및 근거

ORD 기록: ord-1732d0e32f904494a8e94156ec1e36fe
출처 데이터셋: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07476399B2

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