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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Water → 2-bromo-3-(2-butyn-1-yl)-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylic acid-(3-methyl-isoquinolin-1-ylmethyl)-amide

HRID 1453546
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HRID 1453546 반응식
[Br:1][C:2]1[NH:6][C:5]([C:7]([OH:9])=O)=[C:4](/[CH:10]=[CH:11]/[O:12][CH3:13])[N:3]=1.CN(C(ON1N=N[C:24]2[CH:25]=CC=[CH:28][C:23]1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[CH3:36][C:37]1[N:38]=[C:39]([CH2:47][NH2:48])[C:40]2[C:45]([CH:46]=1)=[CH:44][CH:43]=[CH:42][CH:41]=2.O>C(N(CC)CC)C.CN(C)C=O>[CH3:36][C:37]1[N:38]=[C:39]([CH2:47][NH:48][C:7]([C:5]2[N:6]([CH2:28][C:23]#[C:24][CH3:25])[C:2]([Br:1])=[N:3][C:4]=2/[CH:10]=[CH:11]/[O:12][CH3:13])=[O:9])[C:40]2[C:45]([CH:46]=1)=[CH:44][CH:43]=[CH:42][CH:41]=2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 962WaterHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 215066303-Methyl-isoquinolin-1-ylmethylamineHCID 178494817HCID 178494817, 화합물

생성물 1

HCID 689749602-bromo-3-(2-butyn-1-yl)-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylic acid-(3-methyl-isoquinolin-1-ylmethyl)-amide

시약·촉매·용매 2

HCID 6228Dimethylformamide용매
HCID 8471Triethylamine용매

실험 절차

A solution of 3.50 g 2-bromo-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylic acid and 1.30 g TBTU in 1.20 ml triethylamine and 30 ml of dimethylformamide is stirred for 15 min at ambient temperature. Then 1.09 g 3-methyl-isoquinolin-1-ylmethylamine are added, and the resulting suspension is stirred for 4 h at ambient temperature. Then ice-cooled water is added and the precipitate is separated off. The precipitate is dissolved in dichloromethane, the solution is dried over sodium sulphate and the solvent is removed.

후처리

  1. additionis added
  2. customthe precipitate is separated off
  3. dissolutionThe precipitate is dissolved in dichloromethane
  4. dry with materialthe solution is dried over sodium sulphate
  5. customthe solvent is removed

출처 및 근거

ORD 기록
ord-10f19dfeff4a4566a862f23fdec16645
출처 데이터셋
uspto-grants-2009_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07476671B2

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