Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1453579생성일: 2026년 10월 24일
Benzimidazole → 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl) ethoxy]methyl]-9H-purine
https://huagongshe.com/ko/reaction/1453579
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzimidazole | HCID 5798 | — |
| 반응물 | Dibenzyl ether | HCID 7657 | — |
| 반응물 | 2,6-Dichloro-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine | HCID 58285232 | — |
| 반응물 | HCID 178420378 | HCID 178420378 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl) ethoxy]methyl]-9H-purine | HCID 86614102 | 48.8% |
반응 단계
860 mg of product obtained in stage 1 above are mixed with 605 mg of 5-(phenylmethoxy)-1H-benzimidazole (benzyl ether in the 5-position of benzimidazole) and 15 ml of butanol. The mixture is heated at 120° C. for 24 hours. Partial drying, washing with H2O and then drying under vacuum at 50° C. are carried out. 667 mg of 2-chloro-6-[6-(phenylmethoxy)-1H-benzimidazol-1-yl]-9-[[2-(trimethylsilyl)ethoxy]methyl]-9H-purine are obtained, in the form of beige-colored crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07476670B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_01 |
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| ORD ID | ord-f128de6f5f6748459fc36bcee54d9c29 |
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| 출처 메모 | uspto-grants-2009_01 |
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