Indole → 3-(1H-Indol-3-yl)-2-methyl-2,3-dihydro-isoindol-1-one

HRID 1453693노트

반응식

HRID 1453693 반응식
O[CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH3:12].[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14]1>>[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4](=[O:11])[N:3]2[CH3:12])=[CH:14]1

참가 물질

3

반응물 2

HCID 798IndoleHCID 27525883-hydroxy-2-methyl-2,3-dihydro-1H-isoindol-1-one

생성물 1

HCID 533485243-(1H-Indol-3-yl)-2-methyl-2,3-dihydro-isoindol-1-one

실험 절차

The product from example 20, step a) (650 mg, 3.98 mmol) and indole (780 mg, 6.67 mmol) were heated (neat) to 180° C. for 30 minutes. The reaction was cooled to rt and the product was recrystallized from ethanol/water to give 452 mg of the sub-title compound as a tan solid.

후처리

  1. customthe product was recrystallized from ethanol/water

출처 및 근거

ORD 기록
ord-571381b52c034151af58cc46b10869b1
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07476667B2

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