Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1453837생성일: 2026년 10월 26일
Cesium carbonate → Dimethyl 4-benzyloxy-1-{2-[(tert-butoxycarbonyl)amino]-1-(ethoxycarbonyl)ethyl}-1H-pyrazole-3,5-dicarboxylate
https://huagongshe.com/reaction/1453837
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | dimethyl 4-benzyloxy-1H-pyrazole-3,5-dicarboxylate | HCID 57528491 | — |
| 반응물 | Ethyl 3-[(tert-butoxycarbonyl)amino]-2-(methylsulfonyloxy)propanoate | HCID 86617817 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Dimethyl 4-benzyloxy-1-{2-[(tert-butoxycarbonyl)amino]-1-(ethoxycarbonyl)ethyl}-1H-pyrazole-3,5-dicarboxylate | HCID 68952340 | — |
반응 단계
To a solution of dimethyl 4-benzyloxy-1H-pyrazole-3,5-dicarboxylate (4.0 g, 13.8 mmol) and ethyl 3-[(tert-butoxycarbonyl)amino]-2-(methylsulfonyloxy)propanoate (4.29 g, 13.8 mmol) in anhydrous CH3CN (200 mL) was added Cs2CO3 (4.49 g, 13.8 mmol). The mixture was heated to 50° C. overnight, cooled to room temperature, and filtered. The filtrate was concentrated in vacuo to afford the title product as a pale yellow oil. ES MS (M+H)=506.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07476666B2 |
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| 출처 데이터셋 | uspto-grants-2009_01 |
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| ORD ID | ord-3551b1420a9d47008d3cdb63cd312737 |
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| 출처 메모 | uspto-grants-2009_01 |
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