1,1'-Carbonyldiimidazole → 2-Oxo-3-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine

HRID 1453935

반응식

HRID 1453935 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH:9]1[CH2:14][CH2:13][N:12](CC2C=CC=CC=2)[CH2:11][CH2:10]1.[C:22](N1C=CN=C1)(N1C=CN=C1)=[O:23]>O1CCCC1>[O:23]=[C:22]1[N:8]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[C:3]2[CH:4]=[N:5][CH:6]=[CH:7][C:2]=2[NH:1]1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 222932454-Amino-3-[(1-benzylpiperidin-4-yl)amino)pyridine

생성물 1

HCID 222931682-Oxo-3-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridine수율 129.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-amino-3-[(1-benzylpiperidin-4-yl)amino)pyridine (2.8 g, 9.9 mmol) and carbonyldiimidazole (3.0 g, 18.5 mmol) in tetrahydrofuran (100 mL) was refluxed overnight. The reaction was cooled, concentrated and partitioned between chloroform (500 mL) and saturated sodium carbonate (100 mL). The organic phase was dried over magnesium sulfate and concentrated to give the title compound (2.8 g). MS 209 (M+1).

후처리

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated
  3. custompartitioned between chloroform (500 mL) and saturated sodium carbonate (100 mL)
  4. dry with materialThe organic phase was dried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-63acbfffda914b29998310485e526553
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07476665B2

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