Win 35428 → 53898-64-9

HRID 1453980

반응식

HRID 1453980 반응식
[C:1]([C@H:5]1[C@@H:11]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:10][C@H:9]2[N:19]([CH3:20])[C@@H:6]1[CH2:7][CH2:8]2)([O:3]C)=[O:2]>O1CCOCC1.O>[C:1]([C@H:5]1[C@@H:11]([C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[CH2:10][C@H:9]2[N:19]([CH3:20])[C@@H:6]1[CH2:7][CH2:8]2)([OH:3])=[O:2]

참가 물질

3

반응물 1

HCID 105056Win 35428

생성물 1

HCID 1086911253898-64-9

시약·촉매·용매 1

HCID 218864351,4-Dioxane--water (1/1)용매

실험 절차

2β-Carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428) (1), is boiled for 24 h in a 1:1 dioxane-water solution. The solvent is removed in vacuo and the residue is almost completely dissolved in CHCl3. Remaining undissolved solid can then be filtered off, toluene can then be added, and the volume of the solution is reduced in vacuo to approximately 25%. Cooling the resulting white suspension in a freezer for 2 h will provide a precipitated solid which can then be isolated by filtration and is washed with cold 1:1 CHCl3-toluene. The solid can then be pumped dry to give the product.

후처리

  1. customThe solvent is removed in vacuo
  2. dissolutionthe residue is almost completely dissolved in CHCl3
  3. filtrationcan then be filtered off
  4. additiontoluene can then be added
  5. temperatureCooling the resulting white suspension in a freezer for 2 h
  6. customwill provide a precipitated solid which
  7. customcan then be isolated by filtration
  8. washis washed with cold 1:1 CHCl3-toluene
  9. customThe solid can then be pumped dry
  10. customto give the product

출처 및 근거

ORD 기록
ord-3550ea0a7d1f4d248e4c52837af96eb5
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07476740B2

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