4-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester → Tert-butyl 4-amino-2-methylpyrrolidine-1-carboxylate

HRID 1454264노트

반응식

HRID 1454264 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([N:13]=[N+]=[N-])[CH2:10][CH:9]1[CH3:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(OC(=O)C)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([NH2:13])[CH2:10][CH:9]1[CH3:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 1

HCID 140411954-Azido-2-methyl-pyrrolidine-1-carboxylic Acid T-butyl Ester

생성물 1

HCID 19354295Tert-butyl 4-amino-2-methylpyrrolidine-1-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The 4-azido-2-methyl-pyrrolidine-1-carboxylic acid t-butyl ester (93.41 mg, 0.41 mmol) was taken up in ethyl-acetate in a Paar vessel. The solution was flushed with argon and Pd/C (100.00 mg) was added to the vessel. The argon atmosphere was replaced by hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen atmosphere was replaced by argon and the solution was filtered through a celite pad. The pad was washed twice with ethyl acetate. The solvent was removed under reduced pressure. The product was used without further purification. Yield 79.65 mg.C10H20N2O2 MS m/e=200.2 (M+).

후처리

  1. customThe solution was flushed with argon and Pd/C (100.00 mg)
  2. additionwas added to the vessel
  3. filtrationthe solution was filtered through a celite pad
  4. washThe pad was washed twice with ethyl acetate
  5. customThe solvent was removed under reduced pressure
  6. customThe product was used without further purification

출처 및 근거

ORD 기록
ord-b020f155c70b428d9f29ab9eba860fc9
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07479495B2

반응 노트

불러오는 중…