2,2,2-trifluoro-N-(2-methyl-5-nitrophenyl)acetamide → N-(5-Amino-2-methyl-phenyl)-2,2,2-trifluoro-acetamide

HRID 1454284노트

반응식

HRID 1454284 반응식
[F:1][C:2]([F:17])([F:16])[C:3]([NH:5][C:6]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:7]=1[CH3:15])=[O:4]>C(OCC)(=O)C>[NH2:12][C:10]1[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([NH:5][C:3](=[O:4])[C:2]([F:1])([F:16])[F:17])[CH:11]=1

참가 물질

3

반응물 1

HCID 8307252,2,2-trifluoro-N-(2-methyl-5-nitrophenyl)acetamide

생성물 1

HCID 22393536N-(5-Amino-2-methyl-phenyl)-2,2,2-trifluoro-acetamide수율 95%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2,2,2-Trifluoro-N-(2-methyl-5-nitro-phenyl)-acetamide-(3.91 g, 15.78 mmol) was taken up in ethyl acetate in a Paar vessel and flushed with argon. Palladium on carbon (400 mg) was added and the argon atmosphere was replaced with hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen was then replaced with argon and the catalyst was removed by filtration through celite. The solvent was removed under reduced pressure to yield 3.27 g of the desired amine. C9H9F3N2O MS m/e=219.1 (M+H).

후처리

  1. customflushed with argon
  2. additionPalladium on carbon (400 mg) was added
  3. customthe catalyst was removed by filtration through celite
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-098daa5d55c747a783bc9d3d2a52bce8
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07479495B2

반응 노트

불러오는 중…