Ethyl Acetate → 2-(3-Amino-4-methyl-benzyl)-isoindole-1,3-dione

HRID 1454289노트

반응식

HRID 1454289 반응식
C[CH:2]([N:12]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[CH:4]=1.[C:23](OCC)(=O)C>>[NH2:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][C:6]=1[CH3:23])[CH2:2][N:12]1[C:13](=[O:22])[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:20]1=[O:21]

참가 물질

3

반응물 2

HCID 8857Ethyl AcetateHCID 223935242-(Methyl-3-nitro-benzyl)-isoindole-1,3-dione

생성물 1

HCID 223935232-(3-Amino-4-methyl-benzyl)-isoindole-1,3-dione

실험 절차

2-(Methyl-3-nitro-benzyl)-isoindole-1,3-dione (0.45 g, 1.52 mmol) was taken up in ethyl acetate in a Paar vessel and flushed with argon. Palladium on carbon (100 mg) was added and the argon atmosphere was replaced with hydrogen at 50 psi. The vessel was shaken for 12 h. The hydrogen was then replaced with argon and the catalyst was removed by filtration through celite. The solvent was removed under reduced pressure to yield 0.40 g of the desired amine. C16H14N2O2 MS m/e=267.3 (M+H).

후처리

  1. customflushed with argon
  2. additionPalladium on carbon (100 mg) was added
  3. customthe catalyst was removed by filtration through celite
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-00909c10e7e543a89f980a971ad5fedc
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07479495B2

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