Hydroxylamine → 51519-20-1

HRID 1454801노트

반응식

HRID 1454801 반응식
C[N:2](C)[CH:3]=[N:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1.N[OH:13]>O1CCCC1>[OH:13][NH:2][CH:3]=[N:4][C:5]1[CH:10]=[N:9][CH:8]=[CH:7][N:6]=1

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 1222947551519-09-6

생성물 1

HCID 13560477151519-20-1

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

A solution of N,N-dimethyl-N′-pyrazin-2-ylimidoformamide (189 g) from Step A in tetrahydrofuran (400 mL) was treated drop wise with 50% aqueous solution of hydroxylamine (245.7 mL) at 0° C., then warmed up to 80° C. for 2.5 h. Tetrahydrofuran was removed by rotoevaporation and the resulting aqueous mixture kept cold in a refrigerator. The resulting solid was filtered and rinsed with cold diethyl ether to yield the desired product.

후처리

  1. customTetrahydrofuran was removed by rotoevaporation
  2. filtrationThe resulting solid was filtered
  3. washrinsed with cold diethyl ether

출처 및 근거

ORD 기록
ord-354e37c2d3d34199aa47b4bed8435fd3
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482336B2

반응 노트

불러오는 중…