3-(Trifluoromethyl)benzenesulfonyl chloride → N-[5-(4-Fluoro-benzyloxymethyl)-6-methyl-pyridin-2-yl]-3-trifluoromethyl-benzenesulfonamide
반응식
[F:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:16])=[N:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[F:19][C:20]([F:32])([F:31])[C:21]1[CH:22]=[C:23]([S:27](Cl)(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:16][S:27]([C:23]3[CH:24]=[CH:25][CH:26]=[C:21]([C:20]([F:19])([F:31])[F:32])[CH:22]=3)(=[O:29])=[O:28])=[N:13][C:14]=2[CH3:15])=[CH:17][CH:18]=1참가 물질
3
실험 절차
This material was prepared in analogy to example 1 from 5-(4-fluoro-benzyloxymethyl)-6-methyl-pyridin-2-ylamine (0.08 g) and 3-(trifluoromethyl)-benzenesulfonyl chloride (0.087 g) as an amorphous orange solid (0.1 g). MS (ESI−): 453.2 ([M−H]−)
출처 및 근거
- ORD 기록
- ord-78c5fccd0102497f87c1b1df8392da3b
- 출처 데이터셋
- uspto-grants-2009_01
- 특허 번호
- US07482341B2
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