Ammonium Hydroxide → 2-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

HRID 1454971노트

반응식

HRID 1454971 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][C:10](=[O:20])[C:11]=2[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[N:7]=1.[NH4+:21].[Cl-].[NH4+].[OH-]>O>[NH2:21][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][C:10](=[O:20])[C:11]=2[C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[N:7]=1

참가 물질

5

반응물 3

HCID 14923Ammonium HydroxideHCID 25517Ammonium ChlorideHCID 575312262-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

생성물 1

HCID 575312362-amino-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

To 2-chloro-5-(2,6-difluorophenyl)-6H-pyrido[1,2-b]pyridazin-6-one (1.1 g, 3.77 mmol) was added NH4Cl (100 mL) and NH4OH (100 mL). The resulting solution was heated to 90° C. and stirred for 16 hrs until complete. The reaction was cooled to ambient temperature and diluted with H2O (500 mL) until a precipitate formed. The solid precipitate was collected and dried to yield the title compound.

후처리

  1. temperatureThe reaction was cooled to ambient temperature
  2. customformed
  3. customThe solid precipitate was collected
  4. customdried

출처 및 근거

ORD 기록
ord-08ee52dc7da84685874ac0be4d7a3057
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482345B2

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