2,5-Dibromopyridine → 5-Bromo-2-(2,6-difluorobenzyl)pyridine

HRID 1454975노트

반응식

HRID 1454975 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[Br-].[F:10][C:11]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:12]=1[CH2:13][Zn+]>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([CH2:13][C:12]2[C:11]([F:10])=[CH:18][CH:17]=[CH:16][C:15]=2[F:19])=[N:3][CH:4]=1

참가 물질

5

반응물 2

HCID 693532,5-DibromopyridineHCID 178505728HCID 178505728, 화합물

생성물 1

HCID 575312355-Bromo-2-(2,6-difluorobenzyl)pyridine

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2,5-dibromopyridine (10 g) in THF was added Tetrakis (2.2 g) and 2,6-difluorobenzylzinc bromide (126 mL, 63 mmol). The reaction was heated to reflux until reaction was complete by TLC. The reaction was cooled to room temperature, filtered through celite, and concentrated in vacuo. The title compound was purified by silica gel (Hexanes/methylene chloride).

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux until reaction
  3. filtrationfiltered through celite
  4. concentrationconcentrated in vacuo
  5. customThe title compound was purified by silica gel (Hexanes/methylene chloride)

출처 및 근거

ORD 기록
ord-32d5028e2bcb45509fcf0f3760b78004
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482345B2

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