1-Cinnamylpiperazine → 2-(Ethoxy)-2-oxoethyl trans-4-(3-phenylprop-2-en-1-yl)piperazine-1-carboxylate

HRID 1454985

반응식

HRID 1454985 반응식
[CH2:1]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:16]([O:18][C:19](=[O:31])[CH2:20][O:21][C:22](OC1C=CC=CC=1)=[O:23])[CH3:17]>C1(C)C=CC=CC=1>[C:4]1(/[CH:3]=[CH:2]/[CH2:1][N:10]2[CH2:15][CH2:14][N:13]([C:22]([O:21][CH2:20][C:19]([O:18][CH2:16][CH3:17])=[O:31])=[O:23])[CH2:12][CH2:11]2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 7268961-CinnamylpiperazineHCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetate

생성물 1

HCID 673055162-(Ethoxy)-2-oxoethyl trans-4-(3-phenylprop-2-en-1-yl)piperazine-1-carboxylate수율 35.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 1.40 g (6.93 mmol) of trans-1-cinnamylpiperazine and 1.74 g (7.76 mmol) of ethyl{[(phenoxy)carbonyl]oxy}acetate (J. Med. Chem., 1999, 42, 277-290) in 15 ml of toluene is heated at 80° C. overnight. It is evaporated to dryness and the residue is taken up in 50 ml of ethyl acetate. It is washed with 2 times 20 ml of water and 1 times 10 ml of saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, eluting with a 50/50 mixture of cyclohexane and ethyl acetate, then with ethyl acetate, to give 0.814 g of product in the form of a pale yellow oil.

후처리

  1. customIt is evaporated to dryness
  2. washIt is washed with 2 times 20 ml of water and 1 times 10 ml of saturated aqueous sodium chloride solution
  3. dry with materialIt is dried over sodium sulphate
  4. customevaporated to dryness
  5. customThe residue is purified by chromatography on silica gel
  6. washeluting with a 50/50 mixture of cyclohexane and ethyl acetate

출처 및 근거

ORD 기록
ord-33fefda3eeda40a3914791a5e94b15c1
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482346B2

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