Oxalyl chloride → 3-Methyloxy-2-phenyl-4-quinolinecarbonyl chloride

HRID 1455516노트

반응식

HRID 1455516 반응식
[CH3:1][O:2][C:3]1[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:5][C:6]2[C:11]([C:12]=1[C:13](O)=[O:14])=[CH:10][CH:9]=[CH:8][CH:7]=2.C(Cl)(=O)C([Cl:25])=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[N:5][C:6]2[C:11]([C:12]=1[C:13]([Cl:25])=[O:14])=[CH:10][CH:9]=[CH:8][CH:7]=2

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 6243483-Methoxy-2-phenylquinoline-4-carboxylic acid

생성물 1

HCID 213546903-Methyloxy-2-phenyl-4-quinolinecarbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Methyloxy-2-phenylquinoline-4-carboxylic acid (200 mg, 0.72 mmol) [J. Med. Chem. 1999, 42, 1053-1065] was suspended in CH2Cl2 (5 mL) at 0° C. and oxalyl chloride (62 μL, 0.72 mmol) was added with stirring. After stirring at 0° C. for 1 h the cooling bath was removed and the solution allowed to stir at room temperature for 18 h. After this time the solvent was evaporated and the crude acid chloride used in the subsequent reaction without further purification.

후처리

  1. stirringAfter stirring at 0° C. for 1 h the cooling bath
  2. customwas removed
  3. stirringto stir at room temperature for 18 h
  4. customAfter this time the solvent was evaporated
  5. customthe crude acid chloride used in the subsequent reaction without further purification

출처 및 근거

ORD 기록
ord-12ece4c756da4312bd7c9d805b68b55c
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482457B2

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