Trifluoroacetic acid → HCID 68822405, 화합물

HRID 1455590노트

반응식

HRID 1455590 반응식
C(OC(=O)[NH:7][CH:8]([CH:11]([C:13]1[O:14][C:15]([CH:18]2[CH2:20][CH2:19]2)=[N:16][N:17]=1)[OH:12])[CH2:9][CH3:10])(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>ClCCl>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH2:7][CH:8]([CH2:9][CH3:10])[C@@H:11]([C:13]1[O:14][C:15]([CH:18]2[CH2:20][CH2:19]2)=[N:16][N:17]=1)[OH:12]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68822601{1-[(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-hydroxy-methyl]-propyl}-carbamic acid tert-butyl ester

생성물 1

HCID 68822405HCID 68822405, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of {1-[(5-cyclopropyl-[1,3,4]oxadiazol-2-yl)-hydroxy-methyl]-propyl}-carbamic acid tert-butyl ester (2.83 g, 9.95 mmol), trifluoro acetic acid (5 mL) in dichloromethane (20 mL) is stirred at room temperature for 2 hrs and concentrated to dryness under reduced pressure to give (S)-2-amino-1-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-butan-1-ol: compound with trifluoro-acetic acid.

후처리

  1. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-83263ca7d82446d986ed9c4baa2e3e93
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482448B2

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