Methanol → 3-(3-Bromo-4-methoxyphenyl)propanoic acid

HRID 1455709노트

반응식

HRID 1455709 반응식
C([O:3][C:4](=[O:16])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([Br:15])[CH:8]=1)C.[OH-].[K+].CO>O>[Br:15][C:9]1[CH:8]=[C:7]([CH2:6][CH2:5][C:4]([OH:16])=[O:3])[CH:12]=[CH:11][C:10]=1[O:13][CH3:14]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 69049487Ethyl 3-(3-bromo-4-methoxyphenyl)propanoate

생성물 1

HCID 45476083-(3-Bromo-4-methoxyphenyl)propanoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

154 g (0.535 mol) of ethyl3-(3-bromo-4-methoxyphenyl)propanoate are mixed with 45 g (0.8 mol) of potassium hydroxide, 600 ml of methanol and 300 ml of water. The mixture is heated at reflux for 3 hours, and the methanol is then evaporated off. The solution obtained is washed with ether; the aqueous phase is acidified and extracted with ether. The organic phase is dried (Na2SO4), and the solvents are evaporated off: white solid (132.7 g; 96%).

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 3 hours
  3. customthe methanol is then evaporated off
  4. customThe solution obtained
  5. washis washed with ether
  6. extractionextracted with ether
  7. dry with materialThe organic phase is dried (Na2SO4)
  8. customthe solvents are evaporated off

출처 및 근거

ORD 기록
ord-9249e0c98ee743babcb237339e0146da
출처 데이터셋
uspto-grants-2009_01
특허 번호
US07482484B2

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