Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2,3,6-Tetrahydropyridine → 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2,3,6-Tetrahydropyridine | HCID 12750 | — |
| 반응물 | 4-(2-Butynyloxy)-5-fluoro-6-chloropyrimidine | HCID 22599717 | — |
| 생성물 | 1-(6-(2-Butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine | HCID 59341148 | 101.4% |
반응 단계
0.2 g of 4-(2-butynyloxy)-6-chloro-5-fluoropyrimidine and 0.25 g of 1,2,3,6-tetrahydropyridine were mixed and left for 3 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.25 g of 1-(6-(2-butynyloxy)-5-fluoropyrimidin-4-yl)-1,2,3,6-tetrahydropyridine (hereinafter, referred to as Compound (53)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732448B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-83ad6d2e8682477ebd923d867eee68c3 |
| 출처 메모 | uspto-grants-2010_06 |