(S)-N-Benzyl-2-(Boc-amino)-2-phenylacetamide → (S)-2-Amino-N-benzyl-2-phenyl-acetamide hydrochloride

반응식

C(OC(=O)[NH:7][C@H:8]([C:15](=[O:24])[NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[NH2:7][C@@H:8]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:15]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:24]

참가 물질

반응물 2

HCID 12148799(S)-N-Benzyl-2-(Boc-amino)-2-phenylacetamide

HCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 68955044(S)-2-Amino-N-benzyl-2-phenyl-acetamide hydrochloride

실험 절차

(S)-(Benzylcarbamoyl-phenyl-methyl)carbamic acid tert-butyl ester (0.85 g, 2.50 mmol) was dissolved in HCl/dioxane (10 mL, 4.0M). The mixture was stirred at room temperature overnight. The volatiles were removed under reduced pressure to provide the desired product in quantitative yield.

후처리

customThe volatiles were removed under reduced pressure

출처 및 근거

ORD 기록: ord-6ee7254bd0c14aab8836a77edcd90d5c
출처 데이터셋: uspto-grants-2009_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07482368B2

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