Ethylamine → 6-(Ethylamino)pyridine-3-carboxylic acid

반응식

Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1)[CH3:12]

참가 물질

반응물 2

HCID 6341Ethylamine

HCID 792226-Chloronicotinic acid

생성물 1

HCID 117449946-(Ethylamino)pyridine-3-carboxylic acid수율 84%

반응 조건

온도: 170 °C

실험 절차

6--Chloronicotinic acid (100 g, 0.63 mol) was treated with ethylamine (70% in water, 500 ml). The reaction was sealed in an autoclave and heated to 170° C. for 6 hours. The reaction mixture was evaporated, partially neutralised with concentrated HCl and the pH adjusted to pH5 with galcial acetic acid. The solid product was filtered off and dried in vacuo for 18 hours to give 6-(ethylamino)nicotinic acid (87.8 g, 84%).

후처리

customThe reaction was sealed in an autoclave
customThe reaction mixture was evaporated
filtrationThe solid product was filtered off
customdried in vacuo for 18 hours

출처 및 근거

ORD 기록: ord-5a8f36a83e7a45c1af7568686360ac4b
출처 데이터셋: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05843942

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