Trifluoroacetic acid → Ethyl 6-[2-benzyloxy-5-bromobenzylamino]-3-pyridazinecarboxylate

HRID 1455990노트

반응식

HRID 1455990 반응식
[CH2:1]([O:8][C:9]1[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][C:10]=1[CH2:11][N:12]([C:20]1[N:25]=[N:24][C:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:22][CH:21]=1)C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][C:10]=1[CH2:11][NH:12][C:20]1[N:25]=[N:24][C:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:22][CH:21]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 22105523Ethyl 6-[N-(2-benzyloxy-5-bromobenzyl)-N-(tert-butoxycarbonyl)amino]-3-pyridazinecarboxylate

생성물 1

HCID 22105509Ethyl 6-[2-benzyloxy-5-bromobenzylamino]-3-pyridazinecarboxylate수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of ethyl 6-[N-(2-benzyloxy-5-bromobenzyl)-N-(tert-butoxycarbonyl)amino]-3-pyridazinecarboxylate (2.0 g) and trifluoroacetic acid (25 ml) in CH2Cl2 (25 ml) was allowed to stand for 18 hours. The solvents were evaporated, the residue dissolved in CH2Cl2 and washed with dilute aqueous Na2CO3 solution, dried (MgSO4) and evaporated to give ethyl 6-[2-benzyloxy-5-bromobenzylamino]-3-pyridazinecarboxylate as a solid (1.5 g).

후처리

  1. customThe solvents were evaporated
  2. dissolutionthe residue dissolved in CH2Cl2
  3. washwashed with dilute aqueous Na2CO3 solution
  4. dry with materialdried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-39b2d114c0544e7c992378c21d71dde2
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05843942

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