Methyl 3-oxoheptanoate → HCID 178441198, 화합물

HRID 1455997노트

반응식

HRID 1455997 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.O=[C:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10](OC)=[O:11]>C1(C)C=CC=CC=1>[CH2:14]([C:8]1[CH:9]=[C:10]([OH:11])[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=1)[CH2:15][CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 546075Methyl 3-oxoheptanoateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178441198HCID 178441198, 화합물수율 80.1%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

A suspension of 100 g of 3-aminopyrazole and 190 g of methyl 3-oxoheptanoate in 120 ml of toluene was heated under reflux at 100° C. for 3 hours and cooled. Toluene was distilled off under reduced pressure, and diethyl ether was added to the residue. The crystals precipitated were collected and sequentially washed with diethyl ether and acetonitrile to provide 184 g of 5-n-butyl-7-hydroxypyrazolo[1,5-a]pyrimidine as colorless crystals. The structure and melting point of the compound obtained are shown in Table 1 below.

후처리

  1. temperaturewas heated
  2. temperaturecooled
  3. distillationToluene was distilled off under reduced pressure, and diethyl ether
  4. additionwas added to the residue
  5. customThe crystals precipitated
  6. customwere collected
  7. washsequentially washed with diethyl ether and acetonitrile

출처 및 근거

ORD 기록
ord-752420e2becf4e538d295bc827adb042
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05843951

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