4-(2H-1,2,3,4-tetrazol-2-yl)aniline → 4-(2H-Tetrazol-2-yl)phenol

HRID 1456323

반응식

HRID 1456323 반응식
[N:1]1[N:2]([C:6]2[CH:11]=[CH:10][C:9](N)=[CH:8][CH:7]=2)[N:3]=[N:4][CH:5]=1.N([O-])=[O:14].[Na+]>O.S(=O)(=O)(O)O.[Cl-].[Na+].O>[N:1]1[N:2]([C:6]2[CH:11]=[CH:10][C:9]([OH:14])=[CH:8][CH:7]=2)[N:3]=[N:4][CH:5]=1

참가 물질

6

반응물 2

HCID 5716394-(2H-1,2,3,4-tetrazol-2-yl)anilineHCID 23668193Sodium Nitrite

생성물 1

HCID 157603994-(2H-Tetrazol-2-yl)phenol수율 29.6%

시약·촉매·용매 3

HCID 962Water용매4회HCID 1118Sulfuric Acid용매2회HCID 57417360Sodium chloride; water용매

실험 절차

A suspension of 4-tetrazol-2-yl-phenylamine (5.4 g) in water (42 ml ) and conc sulphuric acid (10 ml) was added slowly to a solution of sodium nitrite (2.3 g) in water (8.5 ml) at 5°. The resulting green solution was stirred at this temperature for ca. 30 min, treated with a mixture of water (50 ml) and conc. sulphuric acid (67 ml) and heated to 120° for 1 h. Water (170 ml) was added, the reaction mixture cooled, saturated with brine (100 ml) and extracted with dichloromethane (3×100 ml), dried (Na2SO4) and evaporated to give the title compound as an orange solid (1.6 g).

후처리

  1. temperatureheated to 120° for 1 h
  2. extractionextracted with dichloromethane (3×100 ml)
  3. dry with materialdried (Na2SO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-546e14ce15ca41efa8442c3e862ff09f
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05843966

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