Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,6-Dichloropyrimidine → 4-Chloro-6-(3,5-dimethylpiperidin-1-yl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 반응물 | 3,5-Dimethylpiperidine | HCID 118259 | — |
| 생성물 | 4-Chloro-6-(3,5-dimethylpiperidin-1-yl)pyrimidine | HCID 59341126 | 66% |
반응 단계
0.3 g of 4,6-dichloropyrimidine and 0.34 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 5 hours at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.3 g of 4-chloro-6-(3,5-dimethylpiperidino)pyrimidine. This compound had the cis/trans diastereomer originated two methyls on the pyperidine ring. The ratio of the cis/trans diastereomer was about 3.1/1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732448B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-d6b2761139a1439abcd16946d8b3148b |
| 출처 메모 | uspto-grants-2010_06 |