2-Chloro-4-fluoro-6-nitrophenol → 2-Chloro-4-fluoro-6-aminophenol Hydrochloride

HRID 1456655노트

반응식

HRID 1456655 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[OH:12].[H][H]>CCO.[Pt]=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([NH2:9])[C:3]=1[OH:12]

참가 물질

5

반응물 2

HCID 37278862-Chloro-4-fluoro-6-nitrophenolHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 221171192-Chloro-4-fluoro-6-aminophenol Hydrochloride수율 141.6%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매

실험 절차

A mixture of compound 711 (23.4 g, 0.122 mol) and platinum oxide (2.3 g) in absolute EtOH (120 mL) was placed under 1 atm of hydrogen and stirred until complete reduction had occurred. The hydrogen was replaced with nitrogen and the reaction was filtered through Celite. The filtrate was diluted with Et2O (300 mL) and gaseous hydrochloric acid was bubbled through the solution to provide a white precipitate. The solid was collected and dried under vacuum to provide 17.1 g of compound 712 as a white solid. ##STR91##

후처리

  1. filtrationthe reaction was filtered through Celite
  2. additionThe filtrate was diluted with Et2O (300 mL) and gaseous hydrochloric acid
  3. customwas bubbled through the solution
  4. customto provide a white precipitate
  5. customThe solid was collected
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-2dcc895c2f8f4a83b59979bb34231267
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05843904

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