Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethylpiperidine → 4-Chloro-6-(cis-3,5-dimethylpiperidino)-5-fluoropyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethylpiperidine | HCID 118259 | — |
| 반응물 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 생성물 | 4-Chloro-6-(cis-3,5-dimethylpiperidino)-5-fluoropyrimidine | HCID 86607460 | — |
| 생성물 | 4-Chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin | HCID 86607469 | — |
반응 단계
0.2 g of 4,6-dichloro-5-fluoropyrimidine and 0.41 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 3/1) were mixed and left for 30 minutes at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.1 g of 4-chloro-6-(cis-3,5-dimethyl piperidino)-5-fluoropyrimidine and 0.05 g of 4-chloro-6-(trans-3,5-dimethylpiperidino)pyrimidin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732448B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f86402b91a3147cea90054d8288cee9e |
| 출처 메모 | uspto-grants-2010_06 |