L-(+)-Cysteine → L-Phenylalanine

참여 물질

반응 단계

(cyclo 30-33)Y1 -Y2 -Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-D-Phe-His-Leu-Leu-Arg-Glu-R18 -Leu-R20 -Nle-R22 -R23 -Ala-R25 -Gln-Leu-Ala-R29 -R30 -Ala-R32 -R33 -R34 -Arg-R36 -Leu-Nle-R39 -R40 -R41 -NH2 wherein Y1 is H or Ac; Y2 is Glu, Glu-Glu, Gln-Glu, Ser-Glu-Glu, Ser-Gln-Glu, or des-Y2 ; R18 is Val or Nle; R20 is Glu, D-Glu, Cys or His; R22 is Ala, D-Ala or Thr; R23 is Arg, Cys, Orn or Lys; R25 is Asp or Glu; R29 is Gln or Glu; R30 is Glu or Cys; R32 is His, D-His, D-Arg, imBzlD-His, D-Nal, D-Glu, D-Ala, D-Pal, D-Dpr(Nic), D-Dpr(isopropyl), D-Aph, D-Amp, D-Iamp, D-Har, D-Agl(Nic), D-Lys(isopropyl), D-Orn, D-Dbu, D-Dpr, D-Hly, D-Hly(Nic), D-Lys(Nic), D-Orn(Nic), D-Orn(isopropyl), D-(alkyl)Arg, D-(dialkyl)Arg or D-(dialkyl)Har; R33 is Lys, Cys or Orn; R34 is Asn or Aib; R36 is Lys or Leu; R39 is Glu or Asp; R40 is Ile or Glu; and R41 is Ile or Ala; and wherein D-Pro may be substituted for either Pro4 or Pro5 ; provided that when R30 is Cys, R33 is Cys; and when R30 is Glu, R33 is Orn or Lys; and provided further that D-Tyr or D-Leu or Phe may be substituted for D-Phe and that a second cyclizing bond may exist between R20 and R23.

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