Ethanol → 5-(4,5-dihydrothiazol-5-yl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 1457021노트

반응식

HRID 1457021 반응식
C([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[C:12]1[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=1)#N.[SH:19][CH2:20][CH2:21][NH2:22].[CH2:23](O)C>>[S:19]1[CH:20]([C:3]2[CH:4]=[C:5]3[C:9](=[CH:10][CH:11]=2)[NH:8][CH:7]=[C:6]3[C:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=2)[CH2:21][N:22]=[CH:23]1

참가 물질

4

반응물 3

HCID 702EthanolHCID 6058CysteamineHCID 149732163-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile

생성물 1

HCID 187971695-(4,5-dihydrothiazol-5-yl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole수율 51%

실험 절차

A mixture of 1.0 gm (4.2 mMol) 5-cyano-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and 0.90 gm (11.7 mMol) 2-mercaptoethylamine in 20 mL ethanol was heated to reflux for 18 hours. The reaction mixture was cooled to room temperature and a colorless crystalline solid formed. The solid was isolated by filtration, washed with ethanol and dried under reduced pressure to provide 0.64 gm (51%) of the title compound.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customa colorless crystalline solid formed
  4. customThe solid was isolated by filtration
  5. washwashed with ethanol
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-331219b6c5d34dbc926527c42b534218
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05846982

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