Dimethylformamide → 2-Bromo-5-(2-oxazolyl)benzeneacetyl chloride

HRID 1457185노트

반응식

HRID 1457185 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[CH:11][N:12]=2)=[CH:4][C:3]=1[CH2:13][C:14]([OH:16])=O.CN(C)C=O.C(Cl)(=O)C([Cl:25])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[CH:11][N:12]=2)=[CH:4][C:3]=1[CH2:13][C:14]([Cl:25])=[O:16]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 221037392-Bromo-5-(2-oxazolyl)benzeneacetic acid

생성물 1

HCID 221035042-Bromo-5-(2-oxazolyl)benzeneacetyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the title compound of Step (B) and 0.048 ml dimethylformamide (DMF) in 19 ml CH2Cl2, oxalyl chloride (2M in CH2Cl2, 2.38 ml, 4.75 mmol) was added. The reaction was stirred at room temperature for 1 hour and concentrated to give the title compound of this step as a gum.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-22120d8aaa6b419794a989583b536f0d
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05846990

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